Irving injured his quad during Monday’s win in Denver. He was originally listed as probable before being ruled out on Wednesday.
This is the fourth game Irving has missed this season having sat out single games for a facial fracture, shoulder soreness, and a left quad contusion. The Celtics are 1-2 without him this season.
Boston is already playing without top reserve guard Marcus Smart, who is set to miss two weeks after lacerating his right hand in a non-basketball injury last week. Shane Larkin, who was held out versus Denver, is listed as questionable against the Knicks due to right knee soreness.
Terry Rozier had been questionable to play in Denver due to a sprained ankle but toughed out 30 minutes with Boston shorthanded.
The Celtics also listed rookie big man Guerschon Yabusele as probable with a sprained ankle that forced him to miss the team’s west coast trip. Boston had called up two-way player Kadeem Allen to add depth given its rash of injuries.
Irving, voted an All-Star starter, is averaging 24.9 points, 5 assists, and 3.7 rebounds over 33 minutes per game in 48 appearances for Boston this season. The Celtics sit atop the Eastern Conference but are clinging to a one-game lead over the Toronto Raptors.